منابع مشابه
Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels
Caspase activity during apoptosis is inhibited by physiological concentrations of intracellular K+. To enable apoptosis in injured cortical and hippocampal neurons, cellular loss of this cation is facilitated by the insertion of Kv2.1 K+ channels into the plasma membrane via a Zn2+/CaMKII/SNARE-dependent process. Pro-apoptotic membrane insertion of Kv2.1 requires the dual phosphorylation of the...
متن کاملSurface charge and properties of cardiac ATP-sensitive K+ channels
ATP-sensitive K+ (KATP) channels are present in a wide variety of tissues. The sensitivity of these channels to closure by cytosolic ATP (ATPi) varies significantly among different tissues and even within the same tissue. The purpose of this study was to test the hypothesis that negative surface charges modulate the sensitivity of the KATP channels to ATPi by influencing surface potential in th...
متن کاملSurface Charges of K channels. Effects of strontium on five cloned channels expressed in Xenopus oocytes
The effects of strontium (Sr2+; 7-50 mM) on five different cloned rat K channels (Kv1.1, Kv1.5, Kv1.6, Kv2.1, and Kv3.4), expressed in oocytes of Xenopus laevis, were investigated with a two-electrode voltage clamp technique. The main effect was a shift of the Gk(V) curve along the potential axis, different in size for the different channels. Kv1.1 was shifted most and Kv3.4 least, 21 and 8 mV,...
متن کاملMicrobial K+ Channels
A survey of the currently available genomes shows that K channels are found in most free-living bacteria, archaea, and protists, indicating early evolution before the divergences of the three major domains of life. Though vertically descended from the primordial K channels, more recent lateral transfers of K channel genes must also have occurred. Variations in the motifs of transmembrane or cyt...
متن کامل-activated K Channels
BK channels modulate neurotransmitter release due to their activation by voltage and Ca 2 . Intracellular Mg 2 also modulates BK channels in multiple ways with opposite effects on channel function. Previous single-channel studies have shown that Mg 2 blocks the pore of BK channels in a voltage-dependent manner. We have confirmed this result by studying macroscopic currents of the mslo1 channel....
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2005
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4401792